[15] Pumas de la UNAM 0-3 Santos Laguna [9] 2021-11-05 01:00
Estadio: Estadio Olímpico Universitario Round: 11
Árbitro: Adonai Escobedo Gonzalez Home Manager: Andrés Lillini Away Manager: Guillermo Almada
Head to Head
| México - Liga MX | 2021/03/05 03:00 | Pumas de la UNAM v Santos Laguna | W | 1-0 |
| México - Liga MX | 2020/09/10 02:06 | Santos Laguna v Pumas de la UNAM | W | 1-2 |
| México - Liga MX | 2020/02/02 03:00 | Santos Laguna v Pumas de la UNAM | D | 1-1 |
| México - Copa MX | 2020/01/30 01:00 | Pumas de la UNAM v Santos Laguna | W | 2-1 |
| México - Copa MX | 2020/01/23 03:00 | Santos Laguna v Pumas de la UNAM | L | 4-2 |
| México - Liga MX | 2019/09/29 17:00 | Pumas de la UNAM v Santos Laguna | W | 2-0 |
| México - Liga MX | 2019/05/05 23:06 | Santos Laguna v Pumas de la UNAM | L | 5-2 |
| México - Liga MX | 2018/11/25 18:00 | Pumas de la UNAM v Santos Laguna | D | 1-1 |
Home History
| México - Liga MX | 2021/10/31 00:06 | Pachuca v Pumas de la UNAM | D | 1-1 |
| México - Liga MX | 2021/10/24 17:00 | Pumas de la UNAM v Tijuana | W | 3-1 |
| México - Liga MX | 2021/10/21 00:00 | León v Pumas de la UNAM | W | 1-2 |
| México - Liga MX | 2021/10/17 17:00 | Pumas de la UNAM v Juárez FC | W | 1-0 |
| Clubes del Mundo - Amistosos | 2021/10/09 01:30 | Club América v Pumas de la UNAM | W | 0-1 |
| México - Liga MX | 2021/10/03 22:00 | Club América v Pumas de la UNAM | L | 2-0 |
| México - Liga MX | 2021/09/26 00:00 | Tigres UANL v Pumas de la UNAM | D | 0-0 |
| México - Liga MX | 2021/09/19 02:00 | Mazatlán F.C. v Pumas de la UNAM | D | 2-2 |
Away History
| México - Liga MX | 2021/10/30 22:00 | Querétaro v Santos Laguna | W | 2-3 |
| México - Liga MX | 2021/10/25 00:06 | Santos Laguna v Toluca | D | 2-2 |
| México - Liga MX | 2021/10/20 00:05 | Club América v Santos Laguna | L | 2-1 |
| México - Liga MX | 2021/10/17 00:00 | Pachuca v Santos Laguna | D | 1-1 |
| México - Liga MX | 2021/10/03 00:06 | Santos Laguna v Mazatlán F.C. | W | 1-0 |
| México - Liga MX | 2021/09/27 00:06 | Santos Laguna v Monterrey | L | 1-2 |
| México - Liga MX | 2021/09/20 02:06 | Santos Laguna v Puebla | D | 1-1 |
| Leagues Cup | 2021/09/15 02:00 | Seattle Sounders v Santos Laguna | L | 1-0 |
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