Estadio: Buccaneer Field Round: 1
Home Manager: Autry Denson Away Manager: Sam Washington
| NCAAF | 2021/10/30 17:00 | Monmouth v North Carolina A&T | L | 35-16 |
| NCAAF | 2021/10/23 18:00 | North Carolina A&T v Hampton | L | 9-30 |
| NCAAF | 2021/10/16 21:00 | North Carolina A&T v Kennesaw State | L | 0-14 |
| NCAAF | 2021/10/09 17:00 | North Alabama Lions v North Carolina A&T | W | 34-38 |
| NCAAF | 2021/10/02 17:00 | Robert Morris Colonials v North Carolina A&T | W | 14-41 |
| NCAAF | 2021/09/25 22:00 | North Carolina Central Eagles v North Carolina A&T | W | 14-37 |
| NCAAF | 2021/09/11 00:00 | North Carolina A&T v Duke | L | 17-45 |
| NCAAF | 2021/09/04 18:00 | North Carolina A&T v Furman | L | 18-29 |
| NCAAF | 2021/10/30 17:00 | Campbell v Charleston Southern | W | 14-27 |
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama Lions | L | 22-45 |
| NCAAF | 2021/10/16 22:00 | Hampton v Charleston Southern | W | 5-35 |
| NCAAF | 2021/10/09 19:00 | Charleston Southern v Robert Morris Colonials | L | 24-31 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | L | 28-31 |
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | L | 41-14 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | W | 38-21 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | W | 7-20 |