Estadio: Hanson Field Round: 1
Home Manager: Jared Elliot Away Manager: Brock Spack
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2019/10/19 18:00 | Illinois State v Western Illinois | W | 28-14 |
| NCAAF | 2018/10/06 19:00 | Western Illinois v Illinois State | W | 16-33 |
| NCAAF | 2017/11/04 17:00 | Illinois State v Western Illinois | L | 14-31 |
| NCAAF | 2015/12/05 19:00 | Illinois State v Western Illinois | W | 36-19 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |
| NCAAF | 2021/10/16 19:00 | North Dakota State v Illinois State | L | 20-0 |
| NCAAF | 2021/10/02 18:00 | Missouri St v Illinois State | L | 41-20 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | L | 17-35 |
| NCAAF | 2021/09/18 23:00 | Illinois State v Eastern Illinois | W | 31-24 |
| NCAAF | 2021/09/11 21:00 | Illinois State v Western Michigan | L | 0-28 |
| NCAAF | 2021/09/04 23:30 | Butler v Illinois State | W | 7-49 |
| NCAAF | 2021/03/20 16:00 | Western Illinois v Illinois State | W | 18-26 |
| NCAAF | 2021/10/23 19:00 | Western Illinois v North Dakota | L | 10-34 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | L | 41-17 |
| NCAAF | 2021/10/09 17:00 | Western Illinois v Indiana State | L | 27-37 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | L | 31-30 |
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | W | 38-35 |
| NCAAF | 2021/09/18 20:00 | East Washington v Western Illinois | L | 62-56 |
| NCAAF | 2021/09/12 00:00 | Western Illinois v Montana | L | 7-42 |
| NCAAF | 2021/09/02 23:00 | Western Illinois v Ball State | L | 21-31 |