Estadio: Johnson Hagood Stadium Round: 1
Home Manager: Brent Thompson Away Manager: Drew Cronic
| NCAAF | 2021/02/27 20:30 | The Citadel v Mercer | W | 28-42 |
| NCAAF | 2019/10/26 18:00 | Mercer v The Citadel | L | 24-35 |
| NCAAF | 2018/09/22 20:00 | The Citadel v Mercer | L | 38-31 |
| NCAAF | 2017/10/07 18:00 | The Citadel v Mercer | W | 14-24 |
| NCAAF | 2021/10/23 22:00 | Wofford v Mercer | W | 14-45 |
| NCAAF | 2021/10/16 20:00 | VMI v Mercer | L | 45-7 |
| NCAAF | 2021/10/09 19:30 | Mercer v Western Carolina | W | 34-24 |
| NCAAF | 2021/10/02 22:00 | Samford Bulldogs v Mercer | W | 42-45 |
| NCAAF | 2021/09/25 18:00 | Mercer v Furman | W | 24-3 |
| NCAAF | 2021/09/11 20:00 | Mercer v Alabama | L | 14-48 |
| NCAAF | 2021/09/02 23:00 | Mercer v Point University Skyhawks | W | 69-0 |
| NCAAF | 2021/04/17 17:00 | Mercer v Samford Bulldogs | L | 20-44 |
| NCAAF | 2021/10/23 18:00 | Western Carolina v The Citadel | L | 45-31 |
| NCAAF | 2021/10/16 22:00 | The Citadel v Furman | L | 14-24 |
| NCAAF | 2021/10/09 20:30 | The Citadel v East Tennessee State | L | 21-48 |
| NCAAF | 2021/10/02 18:00 | VMI v The Citadel | W | 24-35 |
| NCAAF | 2021/09/18 22:00 | The Citadel v North Greenville Crusaders | W | 45-13 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | L | 38-21 |
| NCAAF | 2021/09/02 23:00 | The Citadel v Coastal Carolina | L | 14-52 |
| NCAAF | 2021/04/17 17:30 | The Citadel v VMI | L | 17-31 |