Estadio: Strawberry Stadium Round: 1
Home Manager: Frank Scelfo Away Manager: Lance Guidry
| NCAAF | 2018/10/27 23:00 | McNeese State Cowboys v Central Arkansas | W | 23-21 |
| NCAAF | 2018/10/20 21:00 | McNeese State Cowboys v Incarnate Word | L | 17-45 |
| NCAAF | 2018/10/06 23:00 | Abilene Christian v McNeese State Cowboys | W | 21-24 |
| NCAAF | 2018/09/29 23:00 | Stephen F. Austin Lumberjacks v McNeese State Cowboys | W | 10-17 |
| NCAAF | 2018/09/22 22:00 | McNeese State Cowboys v BYU | L | 3-30 |
| NCAAF | 2018/09/15 23:00 | Nicholls Colonels v McNeese State Cowboys | W | 10-20 |
| NCAAF | 2018/09/08 23:00 | McNeese State Cowboys v Houston Christian | W | 51-34 |
| NCAAF | 2018/09/01 20:00 | McNeese State Cowboys v Northern Colorado | W | 17-14 |
| NCAAF | 2018/10/27 18:00 | Sam Houston State Bearkats v SE Louisiana Lions | L | 28-25 |
| NCAAF | 2018/10/21 00:00 | SE Louisiana Lions v Abilene Christian | L | 27-48 |
| NCAAF | 2018/10/13 21:00 | Houston Christian v SE Louisiana Lions | W | 52-62 |
| NCAAF | 2018/10/06 21:00 | SE Louisiana Lions v Incarnate Word | L | 34-52 |
| NCAAF | 2018/09/30 00:00 | Northwestern State v SE Louisiana Lions | W | 17-24 |
| NCAAF | 2018/09/22 23:00 | SE Louisiana Lions v Lamar Cardinals | W | 30-24 |
| NCAAF | 2018/09/16 00:00 | Central Arkansas v SE Louisiana Lions | L | 33-25 |
| NCAAF | 2018/09/08 23:00 | SE Louisiana Lions v LSU | L | 0-31 |