Home History
| NCAAF | 2000/11/18 12:00 | Cincinnati v Southern Mississippi | L | 27-24 |
| NCAAF | 2000/11/11 12:00 | UAB v Southern Mississippi | W | 30-33 |
| NCAAF | 2000/11/04 12:00 | Southern Mississippi v Louisville | L | 28-49 |
| NCAAF | 2000/10/28 12:00 | Houston v Southern Mississippi | W | 3-6 |
| NCAAF | 2000/10/14 12:00 | Tulane v Southern Mississippi | W | 24-56 |
| NCAAF | 2000/10/07 12:00 | Southern Mississippi v South Florida | W | 41-7 |
| NCAAF | 2000/09/30 12:00 | Southern Mississippi v Memphis | W | 24-3 |
| NCAAF | 2000/09/23 12:00 | Oklahoma State v Southern Mississippi | W | 6-28 |
Away History
| NCAAF | 2000/11/18 12:00 | West Virginia v East Carolina | L | 42-24 |
| NCAAF | 2000/11/11 12:00 | East Carolina v Houston | W | 62-20 |
| NCAAF | 2000/10/28 12:00 | East Carolina v UAB | L | 13-16 |
| NCAAF | 2000/10/19 12:00 | Louisville v East Carolina | W | 25-28 |
| NCAAF | 2000/10/14 12:00 | East Carolina v Army | W | 42-21 |
| NCAAF | 2000/10/07 12:00 | Memphis v East Carolina | L | 17-10 |
| NCAAF | 2000/09/23 12:00 | East Carolina v Syracuse | W | 34-17 |
| NCAAF | 2000/09/16 12:00 | East Carolina v Tulane | W | 37-17 |
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