[5] Guaireña FC 0-0 River Plate Asuncion [10] 2021-05-10 00:00
Estadio: Estadio Parque del Guaira Round: 15
Árbitro: Juan Eduardo Lopez Home Manager: Troadio Daniel Duarte Away Manager: Ariel Galeano
Head to Head
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guaireña FC | L | 4-2 |
| Copa Sudamericana | 2021/03/18 22:15 | Guaireña FC v River Plate Asuncion | L | 1-2 |
| Paraguay - Primera División | 2021/03/05 21:15 | River Plate Asuncion v Guaireña FC | W | 0-1 |
| Paraguay - Primera División | 2020/11/10 23:45 | River Plate Asuncion v Guaireña FC | W | 1-2 |
| Paraguay - Primera División | 2020/08/12 20:00 | River Plate Asuncion v Guaireña FC | L | 2-1 |
| Paraguay - Primera División | 2020/01/25 21:00 | Guaireña FC v River Plate Asuncion | W | 2-0 |
| Paraguay - 2ª División | 2018/07/29 13:30 | Guaireña FC v River Plate Asuncion | W | 3-0 |
| Paraguay - 2ª División | 2018/04/21 13:30 | River Plate Asuncion v Guaireña FC | L | 3-1 |
Home History
| Paraguay - Primera División | 2021/04/30 22:00 | Club Nacional v Guaireña FC | W | 1-3 |
| Paraguay - Primera División | 2021/04/25 21:45 | Guaireña FC v Cerro Porteño | L | 0-1 |
| Paraguay - Primera División | 2021/04/16 22:00 | Guaireña FC v Club Olimpia | L | 1-2 |
| Paraguay - Primera División | 2021/04/12 00:30 | Club Libertad v Guaireña FC | L | 2-1 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guaireña FC | L | 4-2 |
| Paraguay - Primera División | 2021/04/03 22:15 | Guaireña FC v Sportivo Luqueño | W | 3-0 |
| Paraguay - Primera División | 2021/03/22 21:15 | Guaireña FC v Sol de América | D | 2-2 |
| Copa Sudamericana | 2021/03/18 22:15 | Guaireña FC v River Plate Asuncion | L | 1-2 |
Away History
| Copa Sudamericana | 2021/05/07 00:30 | Peñarol v River Plate Asuncion | L | 3-0 |
| Paraguay - Primera División | 2021/05/03 23:00 | River Plate Asuncion v Club Libertad | L | 1-3 |
| Copa Sudamericana | 2021/04/29 22:15 | Sport Huancayo v River Plate Asuncion | W | 1-2 |
| Paraguay - Primera División | 2021/04/26 22:15 | Sportivo Luqueño v River Plate Asuncion | D | 2-2 |
| Copa Sudamericana | 2021/04/23 00:30 | River Plate Asuncion v Corinthians | D | 0-0 |
| Paraguay - Primera División | 2021/04/18 00:00 | River Plate Asuncion v Sol de América | L | 0-2 |
| Paraguay - Primera División | 2021/04/12 23:00 | Club Guaraní v River Plate Asuncion | L | 2-0 |
| Copa Sudamericana | 2021/04/08 22:15 | River Plate Asuncion v Guaireña FC | W | 4-2 |
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