Estadio: Mississippi Veterans Memorial Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Terry Sims
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | L | 35-29 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | L | 20-14 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State Bulldogs | L | 35-42 |
| NCAAF | 2021/09/25 22:00 | Bethune Cookman v Alabama State | L | 24-38 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | L | 30-27 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | L | 14-63 |
| NCAAF | 2021/09/05 01:00 | Bethune Cookman v UTEP | L | 28-38 |
| NCAAF | 2019/11/23 20:30 | Bethune Cookman v Florida A&M | W | 31-27 |
| NCAAF | 2021/10/16 19:00 | Alabama State v Jackson State | W | 7-28 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | W | 61-15 |
| NCAAF | 2021/09/25 19:00 | Jackson State v Delta State | W | 24-17 |
| NCAAF | 2021/09/19 00:00 | Jackson State v UL Monroe | L | 7-12 |
| NCAAF | 2021/09/11 23:00 | Jackson State v Tennessee State | W | 38-16 |
| NCAAF | 2021/09/05 19:00 | Jackson State v Florida A&M | W | 7-6 |
| NCAAF | 2021/04/10 19:00 | Alabama v Jackson State | L | 52-43 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | L | 34-14 |