Estadio: Eddie G. Robinson Memorial Stadium Round: 1
Home Manager: Broderick Fobbs Away Manager: Terry Sims
| NCAAF | 2021/11/06 19:00 | Grambling State v Arkansas Pine Bluff | L | 26-33 |
| NCAAF | 2021/10/30 20:00 | Grambling State v Florida A&M | L | 3-26 |
| NCAAF | 2021/10/16 19:00 | Texas Southern Tigers v Grambling State | W | 20-34 |
| NCAAF | 2021/10/09 19:00 | Grambling State v Alcorn State | L | 20-24 |
| NCAAF | 2021/10/02 19:00 | Alabama v Grambling State | W | 28-37 |
| NCAAF | 2021/09/25 21:00 | Grambling State v Prairie View | L | 10-24 |
| NCAAF | 2021/09/18 23:00 | Grambling State v Houston | L | 0-45 |
| NCAAF | 2021/09/11 23:00 | Grambling State v Southern Mississippi | L | 0-37 |
| NCAAF | 2021/11/06 16:00 | Alcorn State v Bethune Cookman | W | 31-35 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | L | 12-42 |
| NCAAF | 2021/10/16 17:00 | Prairie View v Bethune Cookman | L | 35-29 |
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | L | 20-14 |
| NCAAF | 2021/10/02 17:30 | Bethune Cookman v South Carolina State Bulldogs | L | 35-42 |
| NCAAF | 2021/09/25 22:00 | Bethune Cookman v Alabama State | L | 24-38 |
| NCAAF | 2021/09/16 23:30 | Alabama v Bethune Cookman | L | 30-27 |
| NCAAF | 2021/09/11 22:30 | Bethune Cookman v Central Florida | L | 14-63 |