[1] Peñarol 2-2 Cerro Largo [2] 2021-11-23 00:45
Estadio: Estadio Campeón del Siglo Round: 13
Home Manager: Jose Mauricio Larriera Away Manager: Danielo Nunez
Head to Head
| Uruguay - Torneo Apertura | 2021/08/06 21:00 | Cerro Largo v Peñarol | W | 0-1 |
| Copa Sudamericana | 2021/04/14 00:30 | Peñarol v Cerro Largo | W | 4-1 |
| Copa Sudamericana | 2021/04/07 00:30 | Cerro Largo v Peñarol | D | 2-2 |
| Uruguay - Torneo Clausura | 2021/02/17 22:30 | Cerro Largo v Peñarol | D | 1-1 |
| Uruguay - Torneo Apertura | 2020/08/27 23:15 | Peñarol v Cerro Largo | W | 2-0 |
| Uruguay - Torneo Clausura | 2019/12/05 23:30 | Peñarol v Cerro Largo | W | 2-1 |
| Uruguay - Torneo Apertura | 2019/06/02 19:00 | Cerro Largo v Peñarol | L | 1-0 |
Home History
| Uruguay - Torneo Clausura | 2021/11/14 19:30 | CA River Plate v Peñarol | D | 1-1 |
| Uruguay - Torneo Clausura | 2021/11/07 22:00 | Peñarol v Liverpool Montevideo | W | 1-0 |
| Uruguay - Torneo Clausura | 2021/11/05 00:30 | Cerrito v Peñarol | W | 1-3 |
| Uruguay - Torneo Clausura | 2021/10/31 19:00 | Peñarol v Nacional De Football | D | 0-0 |
| Uruguay - Torneo Clausura | 2021/10/23 22:00 | Villa Espanola v Peñarol | W | 1-3 |
| Uruguay - Torneo Clausura | 2021/10/20 23:30 | Peñarol v Torque | W | 3-1 |
| Uruguay - Torneo Clausura | 2021/10/17 18:30 | Deportivo Maldonado v Peñarol | L | 1-0 |
| Uruguay - Torneo Clausura | 2021/10/09 18:30 | Rentistas v Peñarol | W | 0-1 |
Away History
| Uruguay - Torneo Clausura | 2021/11/15 12:45 | Cerro Largo v Rentistas | D | 1-1 |
| Uruguay - Torneo Clausura | 2021/11/08 21:45 | Montevideo Wanderers v Cerro Largo | W | 1-2 |
| Uruguay - Torneo Clausura | 2021/11/04 19:30 | Cerro Largo v Boston River | D | 1-1 |
| Uruguay - Torneo Clausura | 2021/10/31 13:00 | Centro Atlético Fénix v Cerro Largo | W | 1-4 |
| Uruguay - Torneo Clausura | 2021/10/25 16:45 | Cerro Largo v Plaza Colonia | W | 1-0 |
| Uruguay - Torneo Clausura | 2021/10/21 14:00 | IA Sud America v Cerro Largo | D | 0-0 |
| Uruguay - Torneo Clausura | 2021/10/17 15:30 | Cerro Largo v Club Atlético Progreso | W | 1-0 |
| Uruguay - Torneo Clausura | 2021/10/08 23:00 | Cerro Largo v Deportivo Maldonado | D | 1-1 |
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