Estadio: Roy Kidd Stadium Round: 1
Home Manager: Walt Wells Away Manager: Chris Willis
| NCAAF | 2022/10/15 23:00 | Jacksonville State v North Alabama Lions | L | 47-31 |
| NCAAF | 2022/10/08 22:00 | North Alabama Lions v Kennesaw State | L | 34-40 |
| NCAAF | 2022/09/24 23:00 | Tarleton State v North Alabama Lions | L | 43-28 |
| NCAAF | 2022/09/17 22:00 | North Alabama Lions v Tennessee Chattanooga | L | 14-41 |
| NCAAF | 2022/09/10 23:00 | North Alabama Lions v Virginia Wise Highland Cavaliers | W | 49-17 |
| NCAAF | 2022/09/01 22:00 | North Alabama Lions v Indiana State | L | 14-17 |
| NCAAF | 2021/11/20 18:00 | North Alabama Lions v Hampton | W | 35-27 |
| NCAAF | 2021/11/13 20:00 | Kennesaw State v North Alabama Lions | L | 28-24 |
| NCAAF | 2022/10/15 22:00 | Sam Houston State Bearkats v Eastern Kentucky | L | 25-17 |
| NCAAF | 2022/10/01 22:00 | Southern Utah Thunderbirds v Eastern Kentucky | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Eastern Kentucky v Austin Peay | L | 20-31 |
| NCAAF | 2022/09/17 22:00 | Charleston Southern v Eastern Kentucky | W | 17-40 |
| NCAAF | 2022/09/10 20:00 | Eastern Kentucky v Bowling Green | W | 59-57 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | L | 34-42 |
| NCAAF | 2021/11/20 19:00 | Jacksonville State v Eastern Kentucky | W | 31-39 |
| NCAAF | 2021/11/13 18:00 | Eastern Kentucky v Sam Houston State Bearkats | L | 28-42 |