[93] Northwestern 23-30 Duke [77] 2021-09-18 20:00
Estadio: Brooks Field at Wallace Wade Stadium Round: 1
Home Manager: David Cutcliffe Away Manager: Pat Fitzgerald
Head to Head
| NCAAF | 2018/09/08 16:00 | Duke v Northwestern | L | 21-7 |
| NCAAF | 2017/09/09 16:00 | Northwestern v Duke | L | 17-41 |
| NCAAF | 2016/09/18 00:00 | Northwestern v Duke | W | 24-13 |
| NCAAF | 2015/09/19 16:30 | Duke v Northwestern | W | 10-19 |
| NCAAF | 2008/09/06 12:00 | Duke v Northwestern | W | 20-24 |
| NCAAF | 2007/09/15 12:00 | Northwestern v Duke | L | 14-20 |
| NCAAF | 2003/09/20 12:00 | Duke v Northwestern | W | 10-28 |
| NCAAF | 2002/09/14 12:00 | Northwestern v Duke | W | 26-21 |
| NCAAF | 2001/09/22 12:00 | Duke v Northwestern | W | 7-44 |
| NCAAF | 2000/09/09 12:00 | Northwestern v Duke | W | 38-5 |
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